@fw888888 (for some reason I can't tag you) - Windows and Exchange fixes are totally separate so I do not know that it matters. I think just letting MU do it's thing is OK in this case.
MIJ2021 - also check this (linking to specific scenario): https://docs.microsoft.com/en-us/exchange/troubleshoot/client-connectivity/exchange-security-update-issues#http-500-errors-in-owa-or-ecp
kbegg00 - As already mentioned - yes, you need to install if you move up a CU. That is because currently there is no CU that has April fixes 'built in natively' (that can be expected in June CU)
Prasad3435 - Have you seen a reply from madsholme1165 just few comments back? Basically update from .AddScript() to .AddCommand() will unblock you.