I can confirm issues with the transportservice, that exist in the V1 and V2.
In our case we got mail from internall app that includes .ical Files for calender entries. Those mails got all send to Poision Queue since V1 update. And sometime they cause a restart of Transport Service.
The transport process failed during message processing with the following call stack: Microsoft.Exchange.ExchangeSystem.InvalidTimeZoneException: Time zone id already exists
We suspended all queues removed the mails from that app and resumed the queues.
Today we had 4hours of downtime because of this. We therefore installed the V2 patch and hoped it would fix the issue but the issues stays the same. Even with the disabled P2From decetion via Settings override.
We now had to stopp the internal app to send mails at all. But from our understanding this could happen with any mail containing .ical attachment