Me Too!
We had the same thing with our distribution lists a few years ago. We had about five of them for the whole organization (thousands or addresses all together).
Someone decided to send a presentation file to all the lists which regarded the entire organization. One guy failed to open the attachement (the security setting was too high) and replied to all saying "I didn't get the file".
This was replied by a lot of people replying to all with messages like "Me too!", "Stop emailing me!", "What's up, everyone?", "X Y, I know you're responsible for this!" (X Y being a guy's name (who had nothing to do with the matter)), "All of you will be fired" (This was sent by one of the high level bosses), etc.
Eventually, they removed everyone's rights to send mail to these lists except for admins...
Another way of dealing with these kind of things... :)