Of my own experience, we had 6 servers that needed a double reboot post applying that reg key for whatever reason. Signs were msot easily detected by running "get-mailboxdatabase -status" and you would get back an error along the lines of "Exchange can't get the size and the available space of the database" plus of course OWA access would fail.. Since then I've had no issues beyond the weird store status when running this command and wonndered if anyone else could try it and see if they get similar results.. This is Exchange SE sitting on Server 2025 (all latest patches applied) as part of a 6 node DAG.
Get-ServerHealth <your_server> | Where-Object {$_.AlertValue -eq "unHealthy"} |Format-Table HealthSetName,Name,AlertValue -AutoSize
HealthSetName Name AlertValue
------------- ---- ----------
Store StoreMaintenanceAssistantMonitor Unhealthy
Store DirectoryServiceAndStoreMaintenanceAssistantMonitor Unhealthy
Store StoreUrgentMaintenanceAssistantMonitor Unhealthy
Store StoreOnlineIntegrityCheckMaintenanceAssistantMonitor Unhealthy
Store StoreScheduledIntegrityCheckMaintenanceAssistantMonitor Unhealthy
Store StoreCustomerExpectationMaintenanceAssistantMonitor Unhealthy
Store PhysicalDatabaseMaintenanceAssistantMonitor Unhealthy
Store StoreMaintenanceAssistantMonitor Unhealthy
Store DirectoryServiceAndStoreMaintenanceAssistantMonitor Unhealthy
Store StoreUrgentMaintenanceAssistantMonitor Unhealthy
Store StoreOnlineIntegrityCheckMaintenanceAssistantMonitor Unhealthy
Store StoreScheduledIntegrityCheckMaintenanceAssistantMonitor Unhealthy
Store StoreCustomerExpectationMaintenanceAssistantMonitor Unhealthy
Store PhysicalDatabaseMaintenanceAssistantMonitor Unhealthy
Store StoreMaintenanceAssistantMonitor Unhealthy
Store DirectoryServiceAndStoreMaintenanceAssistantMonitor Unhealthy
Store StoreUrgentMaintenanceAssistantMonitor Unhealthy
Store StoreOnlineIntegrityCheckMaintenanceAssistantMonitor Unhealthy
Store StoreScheduledIntegrityCheckMaintenanceAssistantMonitor Unhealthy
Store StoreCustomerExpectationMaintenanceAssistantMonitor Unhealthy
Store PhysicalDatabaseMaintenanceAssistantMonitor Unhealthy