ksccare I would confirm the configuration of the URLs on the Exchange Servers - that it is as expected. I run this command, in Exchange Management Shell, for my customers:
Get-ClientAccessService | sort autodiscoversitescope,name | %{Get-OWAVirtualDirectory "$_\owa (Default Web Site)" -ADPropertiesOnly | FL Server,Name,*url*;Get-ECPVirtualDirectory "$_\ecp (Default Web Site)" -ADPropertiesOnly | FL Server,Name,*url*;Get-OABVirtualDirectory "$_\OAB (Default Web Site)" -ADPropertiesOnly | FL Server,Name,*url*;Get-WebServicesVirtualDirectory "$_\EWS (Default Web Site)" -ADPropertiesOnly | FL Server,Name,*url*;Get-ActiveSyncVirtualDirectory -Identity "$_\Microsoft-Server-ActiveSync (Default Web Site)" -ADPropertiesOnly | FL Server,Name,*url*; Get-MAPIVirtualDirectory -Server $_ -ADPropertiesOnly | FL Server,Name,*url*; Get-ClientAccessService -Identity $_| FL Name,Server,AutoDiscoverServiceInternalUri ; Get-OutlookAnywhere "$_\rpc (Default Web Site)" -ADPropertiesOnly | FL ServerName,Name,*hostname}