Find solutions here to fix desktop refers to a location that is unavailable error in Windows 10:
Copy the Desktop folder path under Users to the target location Since the error prompts an incorrect and unavailable desktop location, simply find the desktop folder under Users, and then copy this necessary folder to the path: C:\Windows\system32\config\systemprofile. Step 1. Launch File Explorer in Windows 10, 8.1, 8 or 7, directly go to C drive, click into Users folder and then your username. Find the Desktop folder there. Step 2. Copy the Desktop folder using Ctrl+C or whatever method you get used to. Go and navigate to C:\Windows\system32\config\systemprofile, under systemprofile paste the Desktop folder there. Step 3. Restart your system and check if your problem is fixed.