Sometimes, something triggers an issue where the central part of the screen right above the taskbar becomes unresponsive: cannot click any icon, cannot use it in any fullscreen/borderless application (when it is clicked the app minimizes).
The second issue isn't related to the first one. I have an NVIDIA 1060 6GB using the newest graphic driver. Sometimes when I quit a game and re-enter, the video card is not detected and the game runs with integrated graphics. Video card temperature is 0 and Win+Control+Shift+B does not solve the issue.
Both issues get fixed after a restart, but always reoccur. In the screenshot attached, I highlighted issue #1 area of unresponsive screen