The sizing tool takes into account roughly 3 inputs:
1) The traffic on the DC (PPS)
2) The minimal (base) traffic independent RAM and CPU requirements for AATP sensors
3) The free (available, not maximum) RAM and CPU resources on the DC without AATP
Based on your description it sounds like the typical RAM and CPU consumption of your DCs is higher than what would permit AATP sensors to run properly.
Low available CPU and RAM can definitely offset the calculations a lot.
You didn’t share any numbers (the Azure ATP Summary sheet’s DC table has in each row detailed information about PPS and typical CPU and RAM consumption – perhaps if you shared one of these rows we could make a more educated guess), but offhand it wouldn’t be a good idea to ignore the Sizing Tool’s recommendations.