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Microsoft Defender Antivirus Error Code -2016281112

Brass Contributor

Hello community,


we have a lot of Windows 10 devices where one setting of the Defender Antivirus Configuration (deployed via Intune) has the status error.

We have no third party AV solution active on these devices.

Any ideas how I can find the origin of this error?


2022-01-11 14_34_40-ZPAPC10842 - Microsoft Endpoint Manager admin center und 9 weitere Seiten - Gesc.png

2022-01-11 14_29_06-Setting Details​ - Microsoft Endpoint Manager admin center und 6 weitere Seiten .png


Defender Security Intelligence Update also fails on these devices:

2022-01-11 14_40_02-ZPAPC10842 - Microsoft Endpoint Manager admin center und 10 weitere Seiten - Ges.png





1 Reply

@John Matrix Did you check the event viewer for the affected device to see if there are helpful pointers?

  1. Open Event Viewer.
  2. In the console tree, expand Applications and Services Logs, then Microsoft, then Windows, then Windows Defender.
  3. Double-click on Operational.