This ugly error is back on 2 physical servers (1 Windows Server 2016 and 1 Windows Server 2019) that host Hyper-V VMs. I have tried all prior suggestions (Windows Security reports -2147023293 error when trying to update). This is also occurring with version 1.383.1379.0. The servers are reporting 1.383.1215.0 as the threat definition version currently installed. We are only seeing this on Hyper-V host systems (both are full licensed servers, not Hyper-V Servers).
Mar. 10 Update: Still experiencing the same issue even though already past 1.383.1400.0 for the update.
Update 1.383.1509.0 has successfully applied to both servers. I did open a ticket with MS yesterday so hopefully that made a difference. I will close this thread but wanted to alert everyone to the issue. Please note this was an issue with the updates and the Hyper-V hosts and Microsoft corrected the issue in their update.