After trying on Reddit, Let's try to find an answers here.
I've enabled Microsoft Defender Application Guard for Office for a few test devices/users in our organisation.
I've used Microsoft Endpoint Manager / Endpoint Security for this:
Enable MDAG for Office (not for Edge)Add the network Rules (hidden company specific url parts)Neutral resources (hidden company url)
This configuration works great for Downloads, but doesn't trigger on opening Outlook attachments.
After a lot of searching, I've found the Microsoft Word Trust Center and the tick for Enable Application Guard for Outlook Attachments is off (and greyed out).
Enable Application Guard for Outlook Attachments greyed out
How can I make sure this will be turned on?
Related question 2: Is it possible that this is because I have Safe documents on?