We have an issue with OneDrive for Business with the documents opening in word, & excel (local) that ultamatly was caused by an IE add on 'SharePoint OpenDocuments Class Missing'. I was able to fix it one machine by repairing office. The problem is, now I have a couple thousand other machines that have the same issue. I could push an msi or exe if I could find one that inlcuded the add on, without pushing office. Any ideas?