This is happening to me in the Dev build.
I saw this start in 111.0.1633.0, and unfortunately the update today to 111.0.1652.0 doesn't fix it. Some additional data, if it helps:
- The web application I am running generates PDF reports and opens a new tab to display the PDF. As the other posters have said, the tab opens, it looks like it's about to load, but then the page remains blank
- I have FoxitPDF Reader set as my default PDF viewer, and when I click on the background of the blank page, it brings up the context menu for FoxitPDF
- I noticed that this ONLY occurs if the application is in IE Mode. If I take it out of IE Mode, the PDF displays just fine in the new tab
- I can open the release version of Edge on my machine (109.0.1518.70) and it works fine. But as I said earlier, all the Dev versions worked fine until just recently.