I'm using Office365 for Business - latest iteration.
Windows 10 - latest update
Opened a simple spreadsheet using OneDrive that is saved on my SharePoint server - maybe a 100 cell list of names.
I added and edited additional information over a 75 minute period - nothing fancy - that included adding two additional sheets.
I used the following functions: Concatenate, change row into columns feature, Filter - aplha, includes/excludes txt, copy, paste (some between sheets), delete. No rocket science taking place just vanilla.
I received the famous error (sic) "Clipboard isn't working properly but you can continue to cut and paste" - I cleared the error message and all my data was gone. The only data remaining was the original saved document.